Bromopropane

Chemical property

Bromopropane is a colorless or light yellow transparent liquid, neutral or slightly acidic, sensitive to light, at m.p.-110 ℃, b. p.71 ℃, relative density 1.357 (20 ℃), n20D 1.4341. It can be mixed with alcohols and ethers in any ratio and is slightly soluble in water.

Main uses

Bromopropane, as an organic synthetic raw material, is used in the synthesis of organophosphorus insecticides and acaricides such as thiopropyl phosphorus, propyl phosphorus, and propyl bromophosphate in pesticides. It can also be used in the pharmaceutical, dye, spice industries, and as a raw material for Grignard reagents.

Used in the manufacturing of pharmaceuticals, pesticides, dyes, spices, etc., and also as a raw material for Grignard reagents, as an intermediate for drugs such as thiamine and probenecid.

Used in organic synthesis and pharmaceutical industry.

Bromopropane, as an organic synthetic raw material, is used in the synthesis of organophosphorus insecticides and acaricides such as thiopropyl phosphorus, propyl phosphorus, and propyl bromophos in pesticides. It can also be used in the pharmaceutical, dye, and spice industries, as well as in the synthesis of pharmaceuticals, pesticides, dyes, and spices as a Grignard reagent raw material. It is also used in the manufacturing of pharmaceuticals, pesticides, dyes, and spices as a Grignard reagent raw material for the drug thiopropyl, Intermediate of probenecid.

Production methods

1. It is obtained by reacting n-propanol with hydrobromic acid. Add hydrobromic acid to concentrated sulfuric acid, then add n-propanol, heat and reflux for 0.5 hours. Steam out all the generated bromopropane at 70-75 ℃, wash with concentrated hydrochloric acid, and then neutralize with sodium carbonate to a pH of 7. Dry with anhydrous sodium sulfate, filter, distill the filtrate, collect the 69-74 ℃ fraction to obtain bromopropane.

2. It is obtained by reacting n-propanol with sodium bromide. Heat n-propanol, water, and sodium bromide together until refluxed, maintain 69-72 ℃, add sulfuric acid dropwise, add it, and continue refluxing for 2 hours. Distillation, collect the distillate at 68-100 ℃, wash with sodium carbonate solution to neutral, and then distill to collect the distillate at 68-76 ℃, namely bromopropane. In addition, in the presence of red phosphorus, n-propanol can also react with bromine to prepare bromopropane.

There are two main methods for preparing bromopropane:

1. Obtained by the reaction of n-propanol and hydrobromic acid in the presence of sulfuric acid.

CH3CH2CH2OH [HBr] → [H2SO4] CH3CH2CH2Br

Add hydrobromic acid to concentrated sulfuric acid, then add n-propanol, heat and reflux for 0.5 hours, evaporate all the generated bromopropane at 70-75 ℃, wash with concentrated hydrochloric acid, neutralize with sodium carbonate to pH=7, dry with anhydrous sodium sulfate, filter, distill the filtrate, and collect the 69-74 ℃ fraction to obtain bromopropane.

2. It is obtained by reacting n-propanol with sodium bromide.

CH3CH2CH2OH [HBr] → [H2SO4] CH3CH2CH2Br

Add hydrobromic acid to concentrated sulfuric acid, then add n-propanol, heat and reflux for 0.5 hours, evaporate all the generated bromopropane at 70-75 ℃, wash with concentrated hydrochloric acid, neutralize with sodium carbonate to pH=7, dry with anhydrous sodium sulfate, filter, distill the filtrate, and collect the 69-74 ℃ fraction to obtain bromopropane.

3. It is obtained by reacting n-propanol with sodium bromide.

CH3CH2CH2OH [NaBr] → [H2SO4] CH3CH2CH2Br

Heat n-propanol, water, and sodium bromide together until reflux, maintain at 69-72 ℃, add sulfuric acid dropwise, continue reflux for 2 hours, distill and collect the distillate at 68-100 ℃, wash with sodium carbonate solution to neutral, and then distill. Collect the distillate at 68-76 ℃, which is bromopropane.

Product category

Flammable liquids;

Toxicity classification poisoning;

Acute toxicity oral - rat LD50: 4000 mg/kg; Abdominal cavity mouse LD50: 2530 mg/kg explosive hazard characteristics can explode when mixed with air;

Flammability hazard characteristics: flammable when exposed to open flames, high temperatures, or oxidants; Burning produces toxic bromide smoke.

Storage and transportation characteristics

Ventilation and low-temperature drying in the warehouse;

Store separately from oxidants;

Fire extinguishing agent water, dry powder, carbon dioxide, foam.

Note: The product can be customized according to customer needs.